Islamic resistance, as one of the strategic concepts in the discourse of the Islamic Revolution, is based on principles that are rooted in Quranic teachings and the Prophetic life. The present study aims to identify and analyze the epistemological foundations of Islamic resistance in the thought of Grand Ayatollah Khamenei
This research, emphasizing the concept of "negating the mustache" and the necessity of resisting the hegemony of the ruling system, examines the epistemological and visionary foundations of Islamic resistance.
The findings show that trust and reliance on divine power, acceptance of guardianship, selflessness, human dignity, and support for the oppressed are not only a moral principle, but also an epistemological basis that play an important role in strengthening the individual and collective spirit of resistance.The Supreme Leader's statements also indicate that these principles are important pillars of the Islamic school of resistance and can pave the way for stability, progress, and effective confrontation with internal and external challenges. The research attempts to explain the epistemological foundations of resistance, offering new horizons for cultural policy-making and strengthening Islamic identity in Muslim societies.